Ethylene Oxide Cancer Studies / Ethylene Oxide Cancer Evidence Integration And Dose Response Implications Semantic Scholar
It is used primarily to produce other chemicals including antifreeze. Evidence of an increased risk of cancer of the lymphohematopoietic system and of breast cancer in females.
Ethylene Oxide And Risk Of Lympho Hematopoietic Cancer And Breast Cancer A Systematic Literature Review And Meta Analysis Request Pdf
At room temperature ethylene oxide is a flammable colorless gas with a sweet odor.
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Ethylene oxide cancer studies. ETO causes mammary tumors in mice and has been associated with breast cancer incidence in one small epidemiologic study. In 1959 Dr Lars Ehrenberg and a coworker warned the Swedish authorities that ethylene oxide a common chemical constituted a potential cancer hazard. Stayner et al 1993.
Studies have been conducted to evaluate the carcinogenicity of ethylene oxide in rats and mice that inhaled ethylene oxide. People living and working within approximately two miles of this facility may have been exposed to EtO for the past three decades. Cancer Causes Control 14531539 Article Google Scholar.
Weight of evidence for relevant key characteristics. Ethylene oxide has been shown to cause lymphoid cancer and tumors of the brain lung connective tissue uterus and mammary gland in animals exposed to ethylene oxide by inhalation. Ethylene oxide ETO is a sterilant gas considered to be a human carcinogen due primarily to excess hematopoietic cancer in exposed cohorts.
Because ethylene oxide destroys DNA it can increase the risk of certain cancers. Twenty years later the first epidemiological study and case reports were published indicating an increased cancer. Many have reported being diagnosed with one of the below cancers.
In smaller amounts ethylene oxide is used as a pesticide and a sterilizing agent. For breast cancers the studies indicated slightly lower risk overall but among those in the lowest cumulative EtO exposure category the risk was profoundly lower. Epidemiological studies of ethylene oxide and human cancerlymphohematopoietic cancer results.
Leukemias brain tumors lung tumors and other cancers have been observed in these animals. EO is used primarily as an intermediate in the production of several industrial chemicals and derivatives of EO are commonly used in several. In conclusion EtO was found to be carcinogenic to humans by inhalation posing a potential human health hazard for lymphoid and breast cancers.
Ethylene oxide was first listed in the Fourth Annual Report on Car-cinogens in 1985 as reasonably anticipated to be a human carcinogen. The ability of ethylene oxide to damage DNA makes it an effective sterilizing agent but also accounts for its cancer-causing activity. The most informative epidemiological inves-tigation of ethylene oxide and cancer risk was a study by NIOSH of more than 18 000 employees at 14 industrial facilities where ethylene oxide was used to sterilize medical supplies or food spices or to test the sterilizing equipment Steenland et al 1991.
2435 For LHM the studies rated as medium or high quality demonstrated no increase or decreased risk although some sporadic associations were reported for specific categories of LHM with no consistency across studies or. Increases in the risk of lymphohematopoietic cancer have been seen in most but not all of the epidemiological studies of EtO-exposed workers manifested as an increase either in leukemia or in cancer of the lymphoid tissue. Studies show that long-term exposure to ethylene oxide can cause cancers of the white blood cells in humans including non-Hodgkin lymphoma myeloma and lymphocytic leukemia according to the EPA.
Ethylene oxide is known to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in humans including epi-demiological studies and studies on mechanisms of carcinogenesis. 1 EPA has concluded that ethylene oxide is carcinogenic to humans by the inhalation route of exposure. Critically both noted that the epidemiological evidence based on lymphoid and breast cancers was limited but that the evidence in animal studies was sufficient and extensive respectively and that EtO is genotoxic.
Steenland K Whelan E Deddens J Stayner L Ward E 2003 Ethylene oxide and breast cancer incidence in a cohort study of 7576 women United States. More and more health department in many countries believe that ethylene oxide may be a human carcinogen. Determine the hazards of the carcinogen Ethylene Oxide.
The International Agency for Research on Cancer IARC and the United States Environmental Protection Agency USEPA classified ethylene oxide EtO as a known human carcinogen. Summary of epidemiological results on ethylene oxide and female breast. 75-21-8 is a highly reactive chemical produced in large volumes.
The study concludes that the cancer risk around Sterigenics is 64 times the acceptable limit solely because of Sterigenics negligent emissions. Ethylene oxide EO CAS no. It also increases the risk of breast cancer in women.
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Ethylene Oxide Cancer Evidence Integration And Dose Response Implications Semantic Scholar
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Pdf Ethylene Oxide Cancer Evidence Integration And Dose Response Implications
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